Stress significantly contributes to cardiovascular diseases such as Takotsubo syndrome (TTS), which mimics an acute coronary syndrome without coronary obstruction. TTS is triggered by surgery, trauma, and emergency treatments in patients, and is reproduced in animal models by a catecholamine surge that impacts cardiac sympathetic innervation. The action of catecholamines on energy metabolism is well documented in the heart, less so in the brain. We investigated the effects of acute catecholaminergic stress on regional cerebral glucose metabolism and interregional metabolic organization in a TTS rat model using FDG-PET and quantitative two-tissue compartment modeling.

Within RETIMAGER and in a joint participation between Inserm and UCM, we have made an Open Access publication at ScienceDirect, called “Stress-induced takotsubo syndrome: dynamic changes in regional cerebral metabolism revealed by quantitative PET imaging”, where we detail our investigations and the results obtained.

This Open Access publication can be accessed through the following link:

Stress-induced takotsubo syndrome: dynamic changes in regional cerebral metabolism revealed by quantitative PET imaging – ScienceDirect

And also in our Dissemination material – Retimager page.

Congratulations, team!